WebMar 10, 2024 · Cryptotanshinone (CTS) is a lipophilic constituent of Salvia miltiorrhiza, with a broad-spectrum anticancer activity. We have observed that CTS enhances the efficacy of gefitinib in human lung cancer H1975 cells, yet little is known about its molecular mechanism. To explore how CTS enhances H1975 cell sensitivity to gefitinib, we figured … WebAug 13, 2024 · Hepatocellular carcinoma (HCC) is a fatal and dominant form of liver cancer that currently has no effective treatment or positive prognosis. In this study, we explored the antitumor effects of cryptotanshinone (CPT) against HCC and the molecular mechanisms underlying these effects using a systems pharmacology and experimental validation …
丹参、泽泻对非酒精性脂肪肝大鼠脂代谢及纤溶系统的影响-韩雪段 …
WebSep 2, 2024 · 2.1. Cryptotanshinone Delayed Progressive Paralysis of AD C. elegans and Decreased the Ratio of Exogenous Serotonin-Induced Acute Paralysis . Aβ-induced neurotoxicity is one of the most important features of Alzheimer’s disease [].To further evaluate the effect of CTS treatment on Aβ-induced pathology, a temperature-sensitive C. … Web建立了高效液相色谱法测定复方丹参片中丹参酮ⅡA的方法。方法简便、准确、灵敏度高、重现性好,共存组份无干扰。经考察市售七个生产厂家的产品,含量差异非常显著,提示生产厂家应在原料药材与生产过程中注意丹参酮ⅡA的含量。建议对复方丹参片进行丹参酮ⅡA的含量 … marvel craft helicopters
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WebCryptotanshinone is a STAT3 inhibitor with IC50 of 4.6 μM in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5. Cryptotanshinone … WebAug 26, 2024 · 一,主要化学成分,结构与性质. 丹参含有脂溶性成分和水溶性成分两大部分.脂溶性成分大多为共轭醌,酮类化合物,具有特征的橙黄和橙红色.如丹参酮I,丹参酮IIA,丹参酮IIB,隐丹参酮等.水溶性成分有丹参素,丹参酸甲,乙,丙,原儿茶酸,原儿茶醛等. 丹参酮I (Tanshinone I ... WebCryptotanshinone is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Recently it was discovered that the compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3 ... marvel crafts diy